Program

Monday, 13 May 2024

Welcome

Prof. Dr. Thomas Berg (Head of Hepatology, University Clinics at Leipzig University and host of SBMC 2024)
Prof. Dr. Veronika von Messling (Head of Department 'Life sciences', BMBF)
Prof. Dr. Beat Müllhaupt (Head of Hepatology, University Hospital Zurich and Program Director of LiSyM-Cancer)

Keynote Lecture by Fabian Theis

Talk-Title

Modeling single-cell state and dynamics

Speaker-Info

  • Fabian Theis, Helmholtz Munich, München, DE
MTZ Award

Award Ceremony and presentations by the winners of MTZ®-Award for Systems Medicine 2024: Anne-Marie Rickmann, Simon Syga, Ina Biermayer

Coffee Break

Session 1: From single cell analysis to clinical application

Session 1: Leo van Grunsven

Session-Info

From single cell analysis to clinical application

Talk-Title

Novel insights into liver fibrosis using scRNAseq analysis

Speaker-Info

  • Leo van Grunsven, Vrije Universiteit Brussel, Brussels, BE
Session 1: Bjørn Tore Gjertsen

Session-Info

From single cell analysis to clinical application

Talk-Title

Single cell signaling profiling by mass cytometry for early therapy response evaluation in leukemia

Speaker-Info

  • Bjørn Tore Gjertsen, University of Bergen, Bergen, NO
Session 1: Fabian Coscia

Session-Info

From single cell analysis to clinical application

Talk-Title

Spatial tissue proteomics to assess health and disease

Speaker-Info

  • Fabian Coscia, Max Delbrück Center for Molecular Medicine, Berlin, DE
Session 1: Ayaka Ichikawa

Session-Info

From single cell analysis to clinical application

Talk-Title

ErbB2/HER2 modulates Cyclin D1 and c-Myc dependency at G1/S transition, impacting CDK4 inhibitor sensitivity

Speaker-Info

  • Ayaka Ichikawa, Osaka University, Osaka, JP
Session 1: Zixin Huang

Session-Info

From single cell analysis to clinical application

Talk-Title

SMAD3-mediated feedback regulates state- and ligand-specific dynamics in single cells.

Speaker-Info

  • Zixin Huang, Technical University Darmstadt, Darmstadt, DE
Poster session & Reception

Poster presentations will be selected from submitted abstracts.

Speakers' Dinner

Tuesday, 14 May 2024

Session 2: Mechanistic modeling at the cellular scale proposing intervention strategies

Session 2: Walter Kolch

Session-Info

Mechanistic modeling at the cellular scale proposing intervention strategies

Talk-Title

Digital Twins for precision oncology

Speaker-Info

  • Walter Kolch, University College Dublin, Dublin, IE
Session 2: Jana Wolf

Session-Info

Mechanistic modeling at the cellular scale proposing intervention strategies

Talk-Title

Modeling signal transduction and gene expression in cancer: from information processing to patient specific models

Speaker-Info

  • Jana Wolf, Max Delbrück Center for Molecular Medicine, Berlin, DE
Session 2: Dennis Vitkup

Session-Info

Mechanistic modeling at the cellular scale proposing intervention strategies

Talk-Title

Why do cancer cells need oxygen in hypoxia?

Speaker-Info

  • Dennis Vitkup, Columbia University Data Science Institute, New York, US
Session 2: Elisa Holstein and Severin Bang

Session-Info

Mechanistic modeling at the cellular scale proposing intervention strategies

Talk-Title

Dynamic pathway modeling of TGFβ and GAS6/AXL induced hepatic stellate cell activation in cirrhosis and liver cancer

Speaker-Info

  • Elisa Holstein, German Cancer Research Center, Heidelberg, DE
  • Severin Bang, University of Freiburg, Freiburg, DE
Session 2: David Liaskos

Session-Info

Mechanistic modeling at the cellular scale proposing intervention strategies

Talk-Title

From Receptors to Metabolism: Reconstruction and Analysis of Information Flow in Large-Scale Signaling Networks

Speaker-Info

  • David Liaskos, École Polytechnique Fédérale de Lausanne, Lausanne, CH
Coffee Break

Session 3: Tissue scale modeling and organ communication in systems medicine

Session 3: Thilo Figge

Session-Info

Tissue scale modeling and organ communication in systems medicine

Talk-Title

Image-­based Systems Biology of Fungal Infections in Humans

Speaker-Info

  • Thilo Figge, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, DE
Session 3: Fabian Fröhlich

Session-Info

Tissue scale modeling and organ communication in systems medicine

Talk-Title

From allosteric to cell state plasticity, explaining drug resistance in cancer using mathematical modelling.

Speaker-Info

  • Fabian Fröhlich, The Francis Crick Institute, London, UK
Lunch
Poster session
Session 3: James Glazier

Session-Info

Tissue scale modeling and organ communication in systems medicine

Talk-Title

Multiscale Virtual Tissue Models and Systems Medicine: Working towards Reproducible and Trustworthy Models

Speaker-Info

  • James Glazier, Indiana University Bloomington, Bloomington, US
Session 3: Danish Anwer

Session-Info

Tissue scale modeling and organ communication in systems medicine

Talk-Title

Understanding patient-specific molecular mechanisms in Alzheimer's Disease using in-silico interactome modelling

Speaker-Info

  • Danish Anwer, Chalmers Technical University, Gothenburg, SE
Session 3: Christine Wiggins

Session-Info

Tissue scale modeling and organ communication in systems medicine

Talk-Title

Elucidating B Lymphocyte Control: A Systems Biology Approach to Transcriptional Regulation of Humoral Response

Speaker-Info

  • Christine Wiggins, Massachusetts Institute of Technology, USA, Cambridge, US

Session 4: AI contributions to systems medicine - Diagnosis and therapy monitoring

Session 4: Ivo Sbalzarini

Session-Info

AI contributions to systems medicine - Diagnosis and therapy monitoring

Talk-Title

Morphogen gradients are regulated by porous media characteristics of embryo geometry

Speaker-Info

  • Ivo Sbalzarini, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, DE
Session 4: Hamid Bouchachia

Session-Info

AI contributions to systems medicine - Diagnosis and therapy monitoring

Talk-Title

A Short Overview of AI in Systems Medicine

Speaker-Info

  • Hamid Bouchachia, Bournemouth University, Bournemouth, UK
Coffee Break
Session 4: Georg Langs

Session-Info

AI contributions to systems medicine - Diagnosis and therapy monitoring

Talk-Title

Machine learning in neuroimaging: connecting development, evolution, and reorganization during disease

Speaker-Info

  • Georg Langs, Medical University of Vienna, Vienna, AT
Session 4: Lena Molitor

Session-Info

AI contributions to systems medicine - Diagnosis and therapy monitoring

Talk-Title

Organellomics: AI-driven deep organellar phenotyping of human neurons

Speaker-Info

  • Lena Molitor, Weizmann Institute of Science, Rehovot, IL
Session 4: Nico Kaiser

Session-Info

AI contributions to systems medicine - Diagnosis and therapy monitoring

Talk-Title

Deep learning-based mapping of intact murine kidneys: paving the way to virtual organs

Speaker-Info

  • Nico Kaiser, University Medical Center Hamburg-Eppendorf, Hamburg, DE
Interactive Session: Successful implementation of Systems Biology

In this session researchers from all career levels will present their ideas and approaches how systems biology is implemented and the challenges they see for the future of systems biology.

Speaker-Info

  • Ursula Klingmüller, German Cancer Research Center (DKFZ), Heidelberg, DE
  • Jens Timmer, University of Freiburg, Freiburg, DE
  • Sophia Müller-Dott, Institute for Computational Biomedicine, Heidelberg, DE
  • Chenhao Tong, University of Heidelberg, Mannheim, DE
  • Stefan Höhme, Leipzig University, Leipzig, DE
  • Sebastian Burbano de Lara, German Cancer Research Center (DKFZ), Heidelberg, DE
  • Lorenz Adlung, University Medical Center Hamburg-Eppendorf, Hamburg, DE
Networking Event

At the networking event there will be opportunity to meet and interact with the speakers and participants of the SBMC 2024. The program will be enriched by a popular science presentation. Including local food and DJ music.

Wednesday, 15 May 2024

Keynote Lecture by Ron Heeren

Talk-Title

Spatial biology and systems medicine in the liver and beyond

Speaker-Info

  • Ron Heeren, Maastricht University, Maastricht, NL

Session 5: The future of systems biology

Session 5: Natal van Riel

Session-Info

The future of systems biology

Talk-Title

Personalized computational models and digital twins for precision nutrition and diabetes management

Speaker-Info

  • Natal van Riel, Eindhoven University of Technology, Eindhoven, NL
Session 5: Andreas Raue

Session-Info

The future of systems biology

Talk-Title

Applications of Systems Biology in Drug Research and Development

Speaker-Info

  • Andreas Raue, Novartis Institutes for BioMedical Research, Cambridge, US
Session 5: Liesbet Geris

Session-Info

The future of systems biology

Talk-Title

Building the Virtual Human Twin: an eco-system challenge

Speaker-Info

  • Liesbet Geris, University of Liège, Liège, BE
Coffee Break
Panel discussion: Requirements for systems biology to be translated into the clinic

The Panel Discussion will put the systems medicine developments encountered during the conference into the context of clinical application.

Speaker-Info

  • Andreas Raue, Novartis Institutes for BioMedical Research, Cambridge, US
  • Ulla Ohlms, Patients' Tumor Bank of Hope, München, DE
  • Maria Polychronidou, Molecular Systems Biology, EMBO, Heidelberg, DE
  • Thomas Berg, Leipzig University, Leipzig, DE
  • Ursula Klingmüller, German Cancer Research Center (DKFZ), Heidelberg, DE
  • Stephen Gilbert, Technical University Dresden, Dresden, DE
Closing Remarks & Poster Awards