Publications
Semi-automated isolation of parenchymal and non-parenchymal liver cells from mice and humans with enhanced stellate cell fraction
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Cell & Bioscience
Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis
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Journal of Biological Chemistry
Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity
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The FEBS Journal
Hallucination filtering in radiology vision-language models using discrete semantic entropy
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European Radiology
Benchmarking large language model-based agent systems for clinical decision tasks
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npj Digital Medicine
Prediction of Mutations and Outcome in Gastrointestinal Stromal Tumors with Deep Learning: A Multicenter, Multinational Study
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preprint
Modeling the dynamics of hepatic metabolism: the predominance of 12-hour rhythmicity in metabolic adaptation
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Cellular and Molecular Life Sciences
Human liver cholangiocyte organoids capture the heterogeneity of in vivo liver ductal epithelium
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Cell Reports
Metabolic Signatures of Acinetobacter baumannii and Klebsiella pneumoniae Infections in Acute-on-chronic Liver Failure
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Cellular and Molecular Gastroenterology and Hepatology
Lactococcus A phages predict ACLF while Enterococcus B phages predict bacterial infection in decompensated cirrhosis
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JHEP Reports
MASLD in the oldest-old: lack of association with cognition or functional autonomy and poor predictive utility of the hepatic steatosis index
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GeroScience
Human assembloids recapitulate periportal liver tissue in vitro
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Nature
Stage-dependent effects of systemic ASBT inhibition in a cholestasis-induced cholemic nephropathy mouse model
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JHEP Reports
NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts
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Signal Transduction and Targeted Therapy
Immunoglobulin G binding as a quantitative marker of hepatocellular death across acute and chronic liver injury
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preprint
OmniPath: integrated knowledgebase for multi-omics analysis
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Nucleic Acids Research
Human Hepatocytes in Experimental Steatosis: Influence of Donor Sex and Sex Hormones
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Biomedicines
Diclofenac and acetaminophen dim the acute-phase response but amplify expression of the iron regulator hepcidin in liver cancer cells
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Cell Systems
In Vitro Characterization of the Published Glypican-3-Targeting Peptide TJ12P2 Reveals a Lack of Specificity and Potency
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Pharmaceuticals
Novel Ruthenacarborane–NSAID Conjugates
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Molecules
Towards sustainable lipidomics: computational screening and experimental validation of chloroform-free alternatives for lipid extraction
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Analytical and Bioanalytical Chemistry
Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set
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Nature Communications
Transforming Growth Factor-β Signaling in Alcohol-Associated Liver Disease
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The American Journal of Pathology
AB024. MIST: a weakly supervised deep learning system for multicenter diagnosis of mediastinal tumors
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Mediastinum
Evaluating a population-based screening programme for early detection of liver fibrosis and cirrhosis in primary care in Germany: a cost assessment study
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BMJ Open
SputOMICs identifies common and distinct markers in cystic fibrosis and chronic obstructive pulmonary disease
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preprint
The interplay between biomechanics and cell kinetics explains the spatial pattern in liver fibrosis
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preprint
Investigation and Distinction of Energy Metabolism in Proliferating Hepatocytes and Hepatocellular Carcinoma Cells
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Cells
Deep neural cellular Potts models
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Mouse precision-cut liver and kidney slices: an optimized <i>ex vivo</i> model for acute toxicity testing
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preprint
Overcoming regulatory barriers to the implementation of AI agents in healthcare.
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Nat Med
The barriers for uptake of artificial intelligence in hepatology and how to overcome them
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Journal of Hepatology
ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNgamma/NRF2 signalling.
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JHEP Rep
LC-MS and High-Throughput Data Processing Solutions for Lipid Metabolic Tracing Using Bioorthogonal Click Chemistry.
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Angew Chem Int Ed Engl
Exploring the Role of Peripheral Macrophages in Glioma Progression: The Metabolic Significance of Cyclooxygenase-2 (COX-2)
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International Journal of Molecular Sciences
Integrin beta 1 facilitates non-enveloped hepatitis E virus cell entry through the recycling endosome
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Nature Communications
Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease
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preprint
TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function
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preprint
Patient-specific effects of metformin on the hepatic metabolism in adolescents with metabolic dysfunction-associated steatotic liver disease (MASLD)
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Journal of Molecular Medicine
Comprehensive evaluation of phosphoproteomic-based kinase activity inference
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Nature Communications
The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD
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Hepatology Communications
Non-Alcoholic Beer Influences Glucose and Lipid Metabolism and Changes Body Composition in Healthy, Young, Male Adults
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Nutrients
Carborane‐Based Analogs of Celecoxib and Flurbiprofen, their COX Inhibition Potential, and COX Selectivity Index
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ChemMedChem
Cell Homeostasis or Cell Death—The Balancing Act Between Autophagy and Apoptosis Caused by Steatosis-Induced Endoplasmic Reticulum (ER) Stress
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Cells
Mechanisms underpinning the effect of exercise on the non-alcoholic fatty liver disease: review.
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EXCLI J
ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-beta1 activation.
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Gut
NetworkCommons: bridging data, knowledge, and methods to build and evaluate context-specific biological networks
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Bioinformatics
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation
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Nature Metabolism
Comparison and evaluation of methods to infer gene regulatory networks from multimodal single-cell data
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preprint
Interleukin 1 β suppresses bile acid-induced BSEP expression via a CXCR2-dependent feedback mechanism
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PLOS ONE
PhosX: data-driven kinase activity inference from phosphoproteomics experiments
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Bioinformatics
The TGF-beta1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.
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Biochem Biophys Res Commun
Hepatocellular Cancer Surveillance in Patients with Advanced Chronic Liver Disease.
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NEJM Evid
Beyond hemoglobin: Critical role of 2,3‐bisphosphoglycerate mutase in kidney function and injury
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Acta Physiologica
Pregnancy alters fatty acid metabolism, glucose regulation, and detoxification of the liver in synchrony with biomechanical property changes
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Heliyon
Role of WISP1 in Stellate Cell Migration and Liver Fibrosis
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Cells
Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
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Gut
Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes.
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Hepat Med
Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure.
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Hepatol Commun
Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice.
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EBioMedicine
Comprehensive evaluation of phosphoproteomic-based kinase activity inference (preprint)
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bioRxiv
Thy‐1 restricts steatosis and liver fibrosis in steatotic liver disease
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Liver International
ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress
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Redox Biology
Lysis buffer selection guidance for mass spectrometry-based global proteomics including studies on the intersection of signal transduction and metabolism (preprint)
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bioRxiv
A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage.
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iScience
Impact of Viscosity on Human Hepatoma Spheroids in Soft Core–Shell Microcapsules
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Advanced Healthcare Materials
Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
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Molecular Systems Biology
Insulin Determines Transforming Growth Factor β Effects on Hepatocyte Nuclear Factor 4α Transcription in Hepatocytes
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The American Journal of Pathology
The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC Activation
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Cellular and Molecular Gastroenterology and Hepatology
Extracellular Matrix Protein 1 Attenuates Hepatic Fibrosis by Inhibiting TSP-, ADAMTS-, and MMP-Mediated Latent TGF-β1 Activation
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preprint
Rapid dexamethasone treatment inhibits LPS-induced cytokine storm in mice
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preprint
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
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Neoplasia
Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression
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Cancer Cell International
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
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Nucleic Acids Research
FitMultiCell: simulating and parameterizing computational models of multi-scale and multi-cellular processes.
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Bioinformatics
Epidemiology of liver transplantation and post-LT complications in Germany: nationwide study (2005–2018)
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European Journal of Gastroenterology & Hepatology
Use and outcome of TIPS in hospitalized patients in Germany: A Nationwide study (2007–2018)
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Hepatology Communications
Lysyl Oxidases as Targets for Cancer Therapy and Diagnostic Imaging
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ChemMedChem
Hepatokine‐based identification of fibrotic NASH and improved risk stratification in a multicentre cohort of NAFLD patients
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Liver International
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH
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Journal of Hepatology
An integrative experimental and computational twin modeling approach to understand clonal dynamics in the normal liver
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Journal of Hepatology
Anti-Cancer Prodrug Cyclophosphamide Exerts Thrombogenic Effects on Human Venous Endothelial Cells Independent of CYP450 Activation—Relevance to Thrombosis
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Cells
Myostatin is associated with the presence and development of acute-on-chronic liver failure
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JHEP Reports
Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study
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The Lancet
Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease.
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EMBO Rep
To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure.
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Semin Liver Dis
Endoscopic Advances in Hepatology.
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Semin Liver Dis
Basal MET Phosphorylation is an Indicator of Hepatocyte Dysregulation in Liver Disease (preprint)
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bioRxiv
Hepatic inflammatory responses in liver fibrosis.
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Nat Rev Gastroenterol Hepatol
Sublethal necroptosis signaling promotes inflammation and liver cancer
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Immunity
Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation
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Cell Death & Disease
Gene regulatory network inference in the era of single-cell multi-omics.
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Nat Rev Genet
Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges.
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J Pers Med
Efruxifermin, an investigational treatment for fibrotic or cirrhotic nonalcoholic steatohepatitis (NASH)
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Expert Opinion on Investigational Drugs
Synthesis and In Vitro Biological Evaluation of p-Carborane-Based Di-tert-butylphenol Analogs
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Molecules
Isonimesulide and Its Carborane Analogues as Isoform‐Selective COX Inhibitors and Antitumor Agents
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Advanced Therapeutics
Carborane‐Based Tebufelone Analogs and Their Biological Evaluation In Vitro
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ChemMedChem
Cholangiokines: undervalued modulators in the hepatic microenvironment
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Frontiers in Immunology
Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRγ signaling
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Genes & Diseases
The rationale and study design of two phase II trials examining the effects of BI 685,509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis.
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Trials