Prof. Dr. Johannes Bode

Role in LiSyM-Cancer

Project leader in C-TIP-HCC
Data and samples from time resolved preclinical WD mouse models of MASLD/NAFLD, MASH/NASH, fibrosis, cirrhosis and HCC, co-cultivation models, IF and multicolor flow-cytometry analysis, FACS-based cell sorting, ncounter nanostring technology and single cell sequencing including “CITE-Technology”
Provides serum, plasma and whole blood samples obtained during a TIPS procedure in patients with liver cirrhosis; longitudinal peripheral venous serum, plasma and whole blood samples; HCC tissue samples and corresponding controls from tumor surgeries

Expertise

Expert in clinical, translational and experimental Hepatology, focus on hepato-immunology
Gastroenterology, hepatology, liver cirrhosis & complications
Interventional hepatology - in particular transjugular intrahepatic portocaval shunt (TIPS) insertion
Diagnostic and interventional endoscopy
Liver regeneration
MASLD, MetALD, cirrhosis development and hepatobiliary tumors with a focus on pathogenesis of HCC
Innate Immunity, Macrophages & macrophage polarization, Acute phase response, signal-transduction focusing on stress-kinase signaling and protease-activated receptors.
Pathogen-host interaction
Systems biology

Degrees

Since 2010, appointed W2-Professor for Hepato-Immunology, Medical Faculty, Heinrich-Heine-University of Düsseldorf
2004, Habilitation in internal medicine, Heinrich Heine University Düsseldorf
1997 Doctorate, Immunopathological Laboratory, Eberhard Karls University of Tübingen
1989-1995 Medical studies at the Eberhard Karls University of Tübingen

Professional Experience

Since 2020, Deputy Director, Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf
2012-2020, Head Senior Consultant, Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf
2012 - 2021, Deputy spokesperson and project manager, Collaborative Research Centre 974
Since 2007, Specialist in Gastroenterology
Since 2005, Senior Physician, Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf
2004-2005, University lecturer (C2), Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf
2004 Specialist in internal medicine
2000-2004 Resident, Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf
1998-2000 DFG fellowship, Institute of Biochemistry, RWTH Aachen University (Director: Prof Dr Peter C. Heinrich)
1996-1998 Trainee doctor, then assistant doctor, Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf

Honors and Awards (selection)